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Biomedical applications of magnetic resonance spectroscopy. Variants of MR spectroscopy (in vivo proton 1D MRS, ex vivo proton 1D, 2D HRMAS, in vivo phosphorus MRS) have been used to study tissue metabolism of brain, testis and muscle. Metabolic profiling of ex vivo HRMAS has been combined with gene expression data using shallow and deep learning techniues to improve understanding of the metabolic and genetic substrate of various diseases.
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Neuroimaging of normal and diseased brain (structure, function, connectivity). A variety of methods (volumetrics, brain surface analysis, radiomics, connectomics, etc) have been applied in a variety of diseases with emphasis on brain tumors, motor sidorders and pediatrics. The goal is to find imaging biomarkersfor diagnosis, prognosis and patient monitoring.
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Bridge the gap between behavioral measurements and brain function. The broad, long-term objective of this line of research is to improve therapy efficacy for, and thus the quality of life of stroke patients. MR compatible robotic devices that stimulate brain recovery via motor training are used to support restoration of movement abilities compromised by stroke-induced pathological changes in the brain. Post-stroke neural changes can be monitored (and therefore later predicted) by in vivo state-of-the-art magnetic resonance imaging (MRI) via brain recovery biomarkers and behavioral motor performance improvements.